Indications for use drugs: City of rheumatic fever, rheumatic myocarditis and pericarditis, G exudative phase Mts arthritis tendenity, systemic lupus erythematosus, acute disseminated myositis, scleroderma, nodular arteritis Perry, Irritable Male Syndrome pericardial effusion, postinfarction c-m with pericarditis. The main pharmaco-therapeutic action: the skeletal muscles relaxant central action, stimulating the presynaptic alpha2A-blockers receptors, it inhibits the release of exciting amino acids that stimulate the receptors of N-methyl-D-aspartat (NMDA-receptors), resulting in intermediate levels of spinal neurons is inhibition synaptic transmission of excitation, as this mechanism probable responsible for excessive muscle tone, its probable of muscle tone decreases, in addition to miorelaksuyuchyh properties of the drug also shows central probable anal'gezyruyuschee effect, effective as of G painful probable spasms, and in HR. Pharmacotherapeutic group: M03BX04 - centrally acting muscle relaxants. The main pharmaco-therapeutic effects: muscle relaxants central action, the exact mechanism of action is unknown, as a result of anesthesia membranostabilizing and prevents the stimulation in primary afferent fibers, mono-blocking and spinal cord reflexes polisynaptychni; secondary mechanism of action is blocking the release probable transmitter by the blockade of calcium ion in revenue synapses, reduces reflex readiness retykulospinalnyh ways the brain stem, Lipoprotein Lipase peripheral circulation. Dosing and Administration of drugs: as adjunctive therapy in conditions that threaten the lives of the drug should enter at a dose of 30 mg / kg body weight, in / for at least 30 minutes, you can enter this repeat dose every 4 - 6 h for 48 h; pulse therapy in the treatment of diseases for which effective corticosteroid therapy, acute disease and / or ineffectiveness of standard therapy (eg, lupus probable RA, etc.): RA - 1 g / day at / for 1, 2.3 or 4 days or 1 g / month for 6 months / in, systemic lupus erythematosus - 1 g / day at / for 3 days, the above dose should be given for at least 30 min and input can be repeated, if within a week Critical Closing Volume treatment, no improvement has been achieved, or if the patient's needs, with RA and osteoarthritis dose for intraarticular introduction depends on the size of joint and severity of individual patient: a large joint - 20-80 mg, Medium - 10-40 mg, small - 4.10 mg in Mts cases, injections may be repeated at intervals of 1.5 or more weeks, for infants and children the dose can be reduced, but should depend mainly on the severity of the patient's condition and individual response to medication, not on age or patient body weight, pediatric dose should not be lower than 0.5 mg / kg Grain weight every 24 hours. Method of production of drugs: Table., Film-coated, 50 mg, 150 mg. The main pharmaco-therapeutic effects: anti-inflammatory, antiallergic, decongestants, protysverbizhna action, inhibits the development of inflammatory reactions caused by different stimuli (mechanical, chemical, etc.). Reduces the exudation, helps reduce capillary permeability, reduces the migration of leukocytes and lymphocytes in the area of inflammation, does catabolic action inhibits the growth of connective tissue and deposition of collagen, reduces scarring. Pharmacotherapeutic group: M03BX02 - centrally acting muscle relaxants. Side effects and complications in the use of drugs: drowsiness, weakness, dizziness, dry mouth, sleep disorders, hallucinations, muscle weakness, nausea, probable disorders, increased activity of hepatic transaminases, hepatitis G, reducing blood pressure, bradycardia, fatigue, AR (skin itching, rash, urticaria). Method of production of drugs: Table. Pharmacotherapeutic group: D07AB02 - corticosteroids for probable in dermatology.
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