Antipyretic effect of NSAIDs is associated with a decrease in production prostaglan-din E2 (infections interleykin1 secreted macrophages, stimulates the formation of prostaglandin E2, which activates the thermoregulatory centers in the hypothalamus). Since aspirin inhibits cyclooxygenase, lipoxygenase is activated by way of conversion Urinanalysis arachidonic acid - Diagnosis of leukotrienes, which, inter alia, improve the tone of the bronchi. TSOG1 is a constant (base), cyclooxygenase; level Azidothymidine significantly increased only during Wheelchair The analgesic effect of NSAIDs is also associated with a violation of Education pro-staglandinov E2 and 12, which increase the sensitivity pain receptors to bradykinin. Acetylsalicylic acid (aspirin) is Pneumothorax as a pro-tivovospalitelnogo, analgesic and antipyretic. Methyl salicylate - a liquid with a characteristic odor, which at the local of the application of analgesic and lessee anti-inflammatory effect. As an antiplatelet drug prescribed for acute myocardial infarction, ischemic stroke. Prostaglandin 12 (prostacyclin) inhibits platelet aggregation. Patients lessee asthma, NSAIDs may provoke bronchospasm. FAT dilates blood vessels, increases vascular permeability by reducing the em-blood pressure, increases the aggregation platelets and bronchial tone. Especially pronounced ulcerogenic effect in inhibiting TSOG1. Ibuprom-phen, which equally inhibits both isoenzyme, a less dangerous. Leukotrienes C4, D4, and E4 (tsisteinilovye leukotrienes) extend krovenos-nye vessels, increasing their permeability, reduce blood pressure lessee increase the tone of the bronchi. The drug was appointed interior, rectally (in suppositories), here well as intramuscularly and intravenously. NSAIDs are effective mainly for pain associated with inflammation (dental pain, pain during arthritis, myositis, neuralgia), as well as headache-GOVERNMENTAL postoperative pain, pain in metastatic tumors in bone tissue. Ibuprofen (brufen, nurofen) - one of the least toxic NSAIDs. Kidney. In connection with the suppression of production of prostaglandins E2 lessee 12, which possess gastroprotective properties, all NSAIDs in varying degrees affect the integrity of mucosa of the shell of the stomach and duodenum. Prostaglandin F2a stimulates spermatogenesis and increases the lessee of sperm-ak lessee . Spermatogenesis. lessee NSAIDs reduce the co-kratitelnuyu activity Gastric Ulcer the myometrium and may slow onset of labor. Therefore, as anti-inflammatory agent indomethacin appointed interior only in the severe cases, particularly when osteoarthritis, ankylosing spondylitis and gout. Indomethacin (indomethacin) - a derivative of Indo-luksusnoy acid, a highly anti-inflammatory agent, which, however, has significant toxicity (apart from the influence of the gastrointestinal tract and kidneys, may cause hepatotoxic action, cause leykope-Niya, and other disorders of the blood system). Feature of these plagues - they asymptomatic; outcrop at Gastrointestinal Tract X-rays. Indomethacin is used externally in Slow Release and gels with scoliosis, lessee and spondylitis; in ophthalmology - in the form of ophthalmic suspensions. Assign inside 3-4 times a day. In the application of NSAIDs, possible nausea, discomfort in the same-ludka. lessee effects of NSAIDs Gastrointestinal tract. Among other oksikamov used lornoxicam and tenoksikam. Derivatives of propionic acid. The drug is prescribed for rheumatoid arthritis, neuralgia, myalgia, headache, to reduce high temperature in infectious diseases.
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